Molecular Editing of Flavins for Catalysis

Abstract The diverse activity of flavoenzymes in organic transformations has fascinated researchers for a long time. However, when applied outside an enzyme environment, the isolated flavin cofactor only shows largely reduced activity. This highlights importance embedding reactive isoalloxazine core flavins defined surroundings. latter include crucial non-covalent interactions with amino acid side chains or backbone as well controlled access to reactants such molecular oxygen. Nevertheless, are increasingly laboratory valuable organocatalysts. Chemical modification parent structure is particular interest this context order achieve reactivity and selectivity transformations, which so far known even unprecedented. review aims give systematic overview reported designed catalysts impact each structural alteration. It intended serve source information comparing performance catalysts, but also designing new flavins. Over last few decades, catalysis emerged from proof-of-concept reactions sophisticated transformations. stimulates anticipating catalyst designs solving contemporary challenges synthesis. 1 Introduction 2 N1-Modification 3 N3-Modification 4 N5-Modification 5 C6–C9-Modification 6 N10-Modification 7 Conclusion